Note: this section is intended for veterinary surgeons only and should NOT be used by cat guardians to attempt to treat cats themselves. However, before leaving the page, guardians please download the following to take to your veterinary surgeons:

FIP diagnosis algorithm (this will open in a new window)

Questionnaires for step 1 of the FIP diagnosis algorithm for guardians to complete and give to your veterinarian to save time during your veterinary consultation

FIP treatment summary information sheet – vets, if you don’t want to go through all of this webpage, this sheet cuts to the chase in regards to dosages, etc.

Note - these downloads should open in a new window and in some browsers will simply automatically download.

Click here for printer friendly version (i.e. black writing on white background) (this version is still the old page: until that is updated, you'd be better with the FIP treatment summary which is a printable pdf giving drugs and doses)

Breaking news July 2018 - Dr Pedersen found the cure for FIP!

When I first came to Feline Infectious Peritonitis research, FIP was regarded as an incurable condition. Most reported "recoveries" were probably curable conditions wrongly diagnosed as FIP. However, it is my belief that if diagnosed early enough, some cats with FIP can be cured. With the introduction of feline interferon and more recently, GS-441524, the RNA nucleoside analogue, we now see a glimmer of hope for more than remission of weeks to months - we have hope of complete recovery for some cats, especially those diagnosed in early infection. However, more work requires to be done: even in human beings there is no reliable treatment for chronic inflammation. Therefore the emphasis must still be on totally preventing cats ever developing FIP in the first place, and on accurate diagnosis, so that cats with non-FIP conditions are not needlessly euthanased.

This webpage represents only the personal opinions of the author, not all opinion leaders agree with me.

Remember that many treatments listed here would be off label and that you must inform your client of this fact and have your client sign your practice's legal disclaimer form.

Updates on treatment will appear in the English version of the website before the translated pages.

golddot 1. Double check the diagnosis

golddot 2. Nutrition

golddot 3. ANTIVIRALS

golddot 4. ANTI-INFLAMMATORIES, CORTICOSTEROIDS / IMMUNOSUPPRESSANTS - given to both effusive and non-effusive FIP cases

golddot 5. EFFUSIVE FIP - treatment for cats with wet FIP

golddot 6. NON-EFFUSIVE FIP - treatment for cats with dry FIP

golddot 7. FCoV associated DIARRHOEA 

golddot 8. VITAMINS AND ANTIOXIDANTS

golddot 9. PROGNOSIS AND MONITORING FIP TREATMENT

golddot 10. DRUGS NOT RECOMMENDED

golddot 11. MISCELLANEOUS NOTES

golddot 12. References and further reading

 

1. DOUBLE CHECK THE DIAGNOSIS
Before commencing treatment, make absolutely certain that the cat really does have FIP: around 80% of cases presented to me as non-effusive FIP turn out to have some other condition. Work through the FIP diagnosis algorithm and be sure that the cat ticks most of the boxes of all of the steps. It is essential to ensure that the diagnosis is correct: immunosuppressive drugs will markedly worsen other conditions (such as bacterial peritonitis or pleurisy) and even be fatal in other cases, for example toxoplasmosis, leishmaniasis.

To see me working through FIP diagnosis algorithm on a real life case, watch "Does Pancho Have FIP?" (It will count for 15 minutes of Continuing Professional Development /Veterinary Continuing Education.) Subscribe to my YouTube, Bitchute and dTube channels to see new cases when they are uploaded. Also see the FIP diagnosis webpages.

2. NUTRITION  - this section applies to cats with wet or dry FIP; FCoV associated diarrhoea and asymptomatic healthy FCoV infected cats

The beauty of altering nutrition immediately is that it will help in any condition, not just FIP – and it is safe.  If you have read The China Study, watched Forks Over Knives, or heard Dr Michael Greger’s famous top human killer diseases lecture, you will already be familiar with the enormous impact diet has on preventing, and even curing, most of the main reasons for human deaths - the situation in cats and dogs may well be similar.


It is my opinion that feeding as varied and natural a diet as possible to cats with FCoV infection and FIP is essential: avoiding highly processed, pro-inflammatory grain-based commercial foods (even the expensive so-called “veterinary” diets are usually cereal based). 

Unlike humans, arginine is an essential amino acid in the cat (Morris & Rogers, 1978): this is why they are obligate carnivores. Arginine is essential not only for the urea cycle but also for the normal functioning of monocytes and endothelial cells. To see an animation of feline coronavirus infecting a monocyte/macrophage, and wet FIP developing, visit: http://www.youtube.com/watch?v=6RyI2LI9R9Q


Give real meat daily to augment arginine levels: even just a tablespoonful a day will make a difference to FCoV infected cats.  It is important that the meat or liver come from free range animals because they will have eaten grass which is rich in omega 3. Alternatively, regularly use commercially available real meat based cat foods e.g. Applaws (MPM products, available from the Zooplus website in Europe); Wild Kitty Cat Food. 


Feed cats with FIP a little salmon, sardines, pilchards or other fish rich in omega 3
Increase the anti-inflammatory omega 3 fatty acid content of the cat’s diet (i.e. add sardines, pilchards, salmon, mackerel twice a wk for 6 weeks). Both Applaws and Almo Nature have canned food including real fish. However remember the risk of hypervitaminosis A (excessive laying down of bone at the joints) so be wary of feeding too much real fish – reassess the situation after 6 weeks.

Cereal based foods contain too much omega 6 polyunsaturated fatty acids and too little omega 3, leading to a state of chronic inflammation – we have seen this in human beings over the past couple of decades: an unprecedented rise in inflammatory conditions such as allergies, asthma and arthritis.  We see a similar rise in inflammatory conditions being recognised in the cat.  


Remember to instruct the cat’s guardian in a gradual changeover of the food: to change it over a period of weeks otherwise the cat will wolf down the new food for a few days, then get sick of it and never touch it again!  The way to introduce a new food is to give it for one meal, then go back to the customary diet for the next few meals, then give a little of the new food again, and so on, gradually increasing the frequency of the new foods, until giving a different food every meal becomes the norm for the cat.  To introduce new foods gradually properly will take at least a month.  

FCoV associated diarrhoea helped by chicken and pumpkin cat food
I’ve had remarkable success using Applaws or Almo Nature chicken and pumpkin tinned food in these cases.

You can get a discount on these cat foods at Zooplus by following this link:

 

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3. ANTIVIRALS

Nucleoside analog GS-441524

Another exciting revelation from Dr Pedersen's group is the results of an anti-viral drug called GS-441524. GS-441524 is a nucleoside analogue that terminates the RNA chain of viral RNA-dependent RNA polymerase. Preliminary investigations showed that it was without side effects. Promising results in vitro and in one in vivo experimental study. Murphy et al., 2018. Ten cats were given FIP in an experimental infection and treated with either 2mg/kg (5 cats) or 5 mg/kg: one cat in each group required a further treatment.  The cats were reportedly alive 10 months later. Murphy et al., 2018.
Can be obtained here: http://glixxlabs.com/chemical-products/bioactive-screen-leads-p6/GLXC-12904
Toll-Free #: (855) Go-Glixx (855-464-5499)
Phone #: 781-333-5348
Fax #: 781-333-5368
sales@glixxlabs.com
Glixxlabs will FedEx the drug overseas. 

Dose: GS-441524 treatment at a dosage of 2 or 5 mg/kg SC sid for 2 weeks, repeating the course if clinical signs recur.

Remember that this treatment would be off label and that you should have your client sign your practice's legal disclaimer form.

GC376

GC376 is a 3C-like protease inhibitor antiviral drug, not currently commercially available. In the most recent field trial, 7 of 20 cats experienced remission. Here is a figure from the publication by Prof Pedersen et al:

GC376

As you would expect, the anti-viral was most effective against cats with the acute form of FIP, effusive FIP, but less so against non-effusive FIP.

Updates on this experimental drug can be found at www.sockfip.org.

 

 

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INTERFERON

Interferons are the broad-spectrum antivirals that the body produces. They are fairly species specific, so it is more effective to use feline interferon than human interferon, although the latter is better than nothing.

Feline interferon omega

Human interferon alpha

Feline interferon omega (Virbac, France)
Virbagen Omega (made by Virbac) is recombinant feline interferon omega (IFN omega) is available in many countries now. This product was first used in treatment of FIP by Japanese vet and scientist Takuo Ishida in a study in which 4 cats of 12 completely recovered and two survived 4 and 5 months. Those cats which recovered completely all had the effusive form of FIP and were relatively older cats. This treatment protocol is based on Dr Ishida's:

IFN omega was initially given subcutaneously at 1 MU/kg every other day, and then twice every week for variable period if remission was seen.

Corticosteroid: (dexamethasone 1 mg/kg intrathoracic or intraperitoneal injection once only) or prednisolone. Oral prednisolone was initially given at 2 mg/kg once daily, and the dosage was gradually tapered to 0.5 mg/kg every other day after remission. However, my personal modification of this protocol would be to use meloxicam instead of prednisolone.

I am working alongside vets in practice in the UK to monitor a number of cats being treated with this product. It seems to be very important to begin treatment as soon as possible after the onset of clinical signs. We are seeing success in younger cats too, and even cats with non-effusive FIP. Some cats are being treated orally using 100,000 Units a day. Once diluted (in water or saline) IFN Omega maintains its potency in the fridge for up to 3 weeks, so keep most IFN Omega in the freezer until needed.

Diluting feline interferon
Virbagen Omega comes in vials of 10 million units. It is reconstituted with 1ml of diluent. To get 100,000 Units/ml, divide one vial into 10 x 0.1ml aliquots in 10 one ml syringes and freeze 9 of them. Put 4.9mls of saline or water into a small clean tube and add one of the 0.1mls of Virbagen Omega to it: you now have 5 mls of diluted interferon: store it in the fridge (where it will keep up to 3 weeks). Show the cat's guardian how to withdraw 0.5mls of the diluted interferon (which now has 100,000 units of interferon per dose). Get the cat's guardian to do the syringe filling and the dosing in front of you: we vets are so used to handling syringes that we forget that most people have never handled a syringe in their lives. Some cats will take the interferon on food, but to be certain the cat gets the dose, tilt the head with the mouth closed and introduce into the commisure of the lips, wait until you see the cat swallow before releasing the head.

Remember that reconstituted, diluted Virbagen Omega lasts only up to 3 weeks in the fridge.

Suppliers: Virbagen Omega can be obtained from your Virbac representative. From abroad, it can be bought at Abbeyvet, who can be contacted at enquiries@abbeyvet-export.co.uk.

In the USA, Virbagen Omega is stocked by The Animal Medical Centre, 510 East 62nd Street, New York, NY 10065. Telephone: (212)-329-8724

Reference: Ishida et al, 2004. Journal of Feline Medicine and Surgery. Vol 6 Issue 2 pp 107-110

Human interferon alpha
Dose: Non-effusive feline infectious peritonitis (FIP): 30 i.u./daily or for 7 days at alternate weeks given by mouth.

In effusive FIP 30 i.u./daily can be used, or larger doses of interferon can be given by intramuscular injection daily (104 - 106 i.u. per day). By 6-7 weeks, if the cat is still alive, interferon will no longer work at this dose because the cat will make antibodies against it.

To obtain human interferon-alpha (Roferon or Intron A), write a prescription for your local pharmacist. Obviously, in areas where feline interferon is available it is preferable as it is likely to have more effect than the human interferon.

Diluting human interferon
To get 30 i.u./ml: Intron A can be obtained as 1 million i.u. for about £10.00. Dilute whole vial in one litre of saline, giving 3000 i.u./ml. Put one ml of 3000 i.u./ml into 99ml of saline, to get 30 i.u. per millilitre. Aliquot into 1ml volumes* and freeze for up to a year. Defrost as required, keep refrigerated for up to a week.

*In the UK: 2ml tubes are available from Sarstedt, supplier's ref: 72.694.006. Fax: 0116 236 66099 Tel: 0116 235 9023.

To get 104 i.u./ml put 1 x 1 million i.u. vial of Intron A or Roferon into 99ml sterile saline and divide into 1ml doses and freeze. For 105 i.u./ml use 9mls saline and proceed as above. For 106 i.u./ml use the whole vial.

 

golddot 4. ANTI-INFLAMMATORIES, CORTICOSTEROIDS AND IMMUNOSUPPRESSANTS

Because FIP is an immune mediated disease, therapy includes suppressing the immune response, usually with glucocorticoids. Before embarking on any of the following therapies, it is essential to ensure that the diagnosis is correct, immunosuppressive drugs could markedly worsen other conditions (such as bacterial peritonitis or pleurisy). See Diagnosis of FIP Cats receiving immunosuppressants should also receive antibiotic cover to protect them against other infections. It is also important to maintain the cat's general nutrition status, by adding real meat, vitamins and antioxidants.

Prednisolone

Meloxicam (Metacam, Boehringer Ingelhiem)

Thalidomide

Prednisolone
Prednisolone is the main anti-inflammatory and immunosuppressant used in feline infectious peritonitis, it is safe, tends to make the cat feel better and stimulates his or her appetite. Moreover, prednisolone is inexpensive and available everywhere. However, prednisolone suppresses both the humoral and cell-mediated immune response and it is possible that alternative anti-inflammatory treatments would be more effective in the treatment of FIP:
Hugo and Reading (2015) reported prolonged survival—787 days—in a 4 year old cat with effusive FIP, who they treated with meloxicam and one month of metronidazole and Tramadol.

When prednisolone is used, it is absolutely essential that the doses BE REDUCED: I am frequently shocked to learn of veterinary surgeons who forget the halve the dose of corticosteroids every 7-10 days: for example, this was not done in the Ritz study and 13 of the cats died of secondary bacterial infections.

Prednisolone has the advantage of also being the treatment for lymphocytic cholangitis, which can be mistaken for FIP, so where the diagnosis is in doubt between FIP and lymphocytic cholangitis, prednisolone can be given anyway: the cat with lymphocytic cholangitis has a good chance of recovery, the cat with FIP unfortunately will die. Prednisolone should never be used in cats with toxoplasmosis, or leishmaniasis, neither is it safe in cases of septic peritonitis or pleurisy, which is why cytology is a very important part of effusive FIP diagnosis, as there will be many more white blood cells in the effusion of a cat with sepsis, and a good cytologist will detect the bacteria or fungi.

Dose: 2 mg/kg/sid given by mouth for 10-14 days
         then 1 mg/kg/sid given by mouth for 10-14 days
         then 0.5mg/kg/sid given by mouth for 10-14 days
         then 0.5 mg/kg every other day until recovery or death

Prednisone is not effective in cats

Meloxicam (Metacam, Boehringer Ingelheim)

Provided kidney function and blood pressure are normal, consider using the non-steroidal anti-inflammatory meloxicam instead of corticosteroids.   Meloxicam was used for 119 days, along with one month of metronidazole, in one FIP case report in a cat who survived 787 days. (Hugo and Reading, 2015) Meloxicam, rather than glucocorticoids, was also used in 10 experimentally-infected cats who recovered using an antiviral called GS-441524 (not yet commercially available). (Murphy et al, 2018)

Dose: 0.05 mg/kg BW, PO, q24h

Thalidomide
The rationale of using thalidomide in the treatment of feline infectious peritonitis is to reduce inflammation and the humoral immune response to feline coronavirus while leaving the cell mediated (anti-viral) immune response intact. Only 4 cats with FIP have been treated with thalidomide so far and unfortunately all died. However, one with a thoracic effusion did eliminate his effusion and had a remission of 3 months. I think that, to be effective, thalidomide would need to be used very early in the disease, before too many blood vessels became damaged.

Be sure to obtain the owner's consent for using a drug not licenced for cats.

Dose: 50-100mg at night. CANNOT BE USED IN PREGNANT CATS as it is teratogenic.


golddot 5. EFFUSIVE FIP - treatment for cats with wet FIP

My go-to protocol to treat effusive FIP is to drain the effusion, give Virbagen Omega to the site of the effusion, then s/c eod after resolution of the effusion, and meloxicam or prednisolone (NOT BOTH) as the anti-inflammatory. If you can obtain the anti-FCoV nucleoside analog GS-441524 (Murphy et al, 2018), that would be the treatment of choice.

Doses:

Feline interferon omega: 1 million units/kg/sc/eod until recovery

Meloxicam (provided blood pressure and kidney function are normal): 0.05 mg/kg per os, sid.

 

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golddot 6. NON-EFFUSIVE FIP - treatment for cats with dry FIP

My go-to protocol for non-effusive FIP therapy is Virbagen Omega at 100,000 units per cat per day per os and sliding doses of prednisolone. I have I have little personal experience of Polyprenyl Immunostimulant, my mind is open about its efficacy, but I would love to hear from veterinary surgeons willing to share case histories with me: contact me at draddie [at] catvirus [dot] com.

Diluting feline interferon
Virbagen Omega comes in vials of 10 million units. It is reconstituted with 1ml of diluent. To get 100,000 Units/ml, divide one vial into 10 x 0.1ml aliquots in 10 one ml syringes and freeze 9 of them. Put 4.9mls of saline or water into a small clean tube and add one of the 0.1mls of Virbagen Omega to it: you now have 5 mls of diluted interferon: store it in the fridge (where it will keep up to 3 weeks).

Show the cat's guardian how to withdraw 0.5mls of the diluted interferon (which now has 100,000 units of interferon per dose). Get the cat's guardian to do the syringe filling and the dosing in front of you: we vets are so used to handling syringes that we forget that most people have never handled a syringe in their lives. Some cats will take the interferon on food, but to be certain the cat gets the dose, tilt the head with the mouth closed and introduce into the commisure of the lips, wait until you see the cat swallow before releasing the head.

Remember that reconstituted, diluted Virbagen Omega lasts only up to 3 weeks in the fridge.

Supplier: Virbac

Polyprenyl immunostimulant (PPI) – for treating non-effusive FIP only

PPI is NOT recommended in effusive (wet) FIP.

In the most recent published study by Legendre et al, 2017, survival was better in cats not concurrently treated with systemic corticosteroids, but it is probably safe to use topical ophthalmic corticosteroid treatment along with PPI in cats with intra-ocular signs of non-effusive FIP.
Dose: 3.0 mg/kg orally of Polyprenyl Immunostimulant three times a week.
Cost: about £230 to get 60ml (6x 10ml bottles) including postage from America
To obtain PPI: email orders@vetimmune.com, or visit www.vetimmune.com. 
UK veterinary surgeons will need to apply to the VMD for special import permission.

I found the following video made by a cat's guardian, demonstrating how she doses her pet:

 

 

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golddot 7. FCoV associated DIARRHOEA 

Apologies -t his section is under construction.


golddot 8. VITAMINS AND ANTIOXIDANTS

Vitamin A
Vitamin A is an antioxidant. The dose of Vitamin A is 200 i.u./day given by mouth or in the food. Cats cannot metabolise the beta-carotene form so must be given vitamin A as fish oil, e.g. halibut liver oil. Too much vitamin A can cause excessive laying down of bone at the joints, so don't use this supplement for more than 4-6 weeks.

Vitamin B1 (thiamine)
Vitamin B1 (thiamine): 100 ug/day given orally (i.e. by mouth or in food).

Vitamin B complex

Multivitamins B are a good appetite stimulant and can be obtained from health food shops or chemists (I particularly like the one from Boots). Dose: paediatric dose.

Vitamin C
Ascorbic acid 125 mg twice daily given by mouth or in food. Vitamin C is an antioxidant. Remember that given over a long period of time, vitamin C can predispose to oxalate crystals in the urine.

Vitamin E
Dose of vitamin E: 25-75 i.u./cat twice dailty given by mouth or in food. Vitamin E is an antioxidant.


Other supportive drugs

Aspirin
For anti-inflammatory activity and pain relief.

Dose: 10mg/kg every 48-72 hrs per os.

Antibiotics
Antibiotic cover is essential when immunosuppressing a cat.  Your choice of antibiotics will depend on what your major differential diagnoses are, given the presenting clinical signs.  For example, if you are awaiting FIP confirmation from your laboratory and your major differential diagnoses are toxoplasmosis, or bacterial peritonitis / pleurisy, then clindamycin (Antirobe) will be your antibiotic of choice because it covers both aerobic and anaerobic infections; if your major differential is infectious anaemia, then doxycycline or oxytetracycline will be your choice.  Metronidazole is effective against anaerobic organisms, so is a good choice where bacterial pleurisy is a differential diagnosis.  It inhibits TNF-alpha—i.e. is anti-inflammatory—and was used for one month, along with meloxicam, in one FIP case who survived 787 days. Hugo and Reading, 2015   However, it is horrible to taste and can be difficult to administer to cats.  

Avoid amoxycillin/clavulanic acid because it can inhibit interferon-gamma, which is essential for FIP survival. 

Anabolic steroids
For appetite encouragement and anti-catabolism, especially if the kidneys are affected.

Choose from the following (in the UK):
Laurabolin injection: 2-5mg/kg every 21 days.
Nandrolin injection: 2-5mg/kg as a weekly injection.
Nandoral tablets - one a day either whole or crushed into food.
Retarbolin injection: 1mg/kg every 21 days.
Orandrone tablets: 0.5mg/kg daily (the tablets are 5mg).

Remember to warn the owner that the cat's urine could become more strong smelling with this treatment.
The injectables usually require to be kept in the dark.

Probiotics
Probiotics such as Protexin Pro-Kolin+  can help cats with FCoV associated diarrhoea.

 

 

9. PROGNOSIS AND MONITORING TREATMENT


Whatever treatment you opt for, it is important to monitor the cat's progress. Initially, I measure the haematocrit (Hct), globulins, albumin to globulin ratio (A:G), alpha1-acid glycoprotein (AGP) and the cat's weight every 7-14 days to see how the cat is progressing. Later
, examinations might only be monthly if the cat is doing well. It is not worth measuring the FCoV antibody titre more often than every 2-3 months, there will be no discernible difference within a shorter period. The AGP should be the first to fall if treatment is having a positive effect because AGP is a measure of inflammation. Positive signs are globulin levels decreasing, and the albumin: globulin ratio(A:G) increasing, Hct increasing and reticulocytes appearing in blood smears and weight increasing. Negative signs are AGP remaining high, globulins staying high or increasing, A:G decreasing, weight loss. When Hct gets to below 20% and is non-regenerative (no reticulocytes seen on blood smear examination) then the cat should probably be humanely euthanased if your clinical opinion is that he or she is no longer getting any happiness out of life. Clearly, if the cat is distressed at any point in the treatment, then euthanasia will be required. Sadly, cats with effusive feline infectious peritonitis usually only survive a few days, possibly weeks at best. Cats with non-effusive FIP can last many weeks or months, though after neurological signs begin euthanasia usually ensues fairly rapidly.

For AGP testing see Companion Animal Diagnostics.

Staging for effusive FIP prognosis to help you to assess whether treatment has a chance of helping or not

In this staging system shown in the video below the severity of effusive FIP can be worked out, which will give you an idea of whether or not it is worth obtaining special drugs to treat, or whether it is worthwhile continuing treating a case.  Look at the parameter in the left hand column, then look at where the result of your case falls in the range, then put the score for that parameter into the next free column in the grey shaded cells. Finally work out the total score for your case. You can download the excel file here: http://www.catvirus.com/downloads.html: the total score will automatically fill in the cell at the bottom.

Interpreting the total score for your case:

  • 0-4: survival time more than 2 weeks
  • 5-11: survival time less than 2 weeks
  • over 12: survival time less than 3 days

While this isn’t an absolutely exact predictor, it does give a ballpark indicator of prognosis.
Remember that even giving the cat a few more days can help the cat’s guardian come to terms with the imminent demise of their pet: corticosteroids don’t cost much and will help ease those last days. Draw off the effusion to make the pet more comfortable.  FIP doesn’t seem to be a painful condition.  This is a video I made of using the staging excel file:

 

 

10. NOT RECOMMENDED

L-lysine should NEVER be given to a cat with FCoV infection or FIP because it is antagonistic to arginine which is essential for immune function.

Thromboxane Synthetase Inhibitors

Two cats with abdominal effusions were treated with ozagrel hydrochloride with success (Watari et al, 1998).   However, follow up studies failed to confirm the usefulness of this compound.
Dose: 5-10mg/kg twice daily and prednisolone at 2mg/kg/day.

 

Further reading

""Feline Infectious Peritonitis and Coronavirus" - download an ebook written for cat guardians or purchase the physical version from Amazon.

This book is written for anybody unfortunate enough to have had FIP diagnosed in their cat. It will help you through the maze that is FIP diagnosis, to decide what your options are for treatment and to safeguard your other cats, or how and when to safely add a new cat to your household.

Please note that this is a zip folder containing an .exe file and that you may have to alter your firewall or virus protection program to allow it to download. This is a new experiment for us, so please let us know if you encounter any problems downloading it (email e-books @ catvirus.com). You can still use the regular Buy Now buttons below to purchase the e-book if you prefer.

At present, you can only buy the whole eBook directly (and within minutes) from the sample eBook in US dollars. To buy it in GB pounds or Euros, please use the Paypal links below and we will manually send you an activation key within 24 hours. A physical version can be obtained from any of the Amazon websites.

Note that everything in these books is available for free here on the website!

FIPbook

Download the photographs from the book in colour (this will open as a .pps in a new window).

To buy in UK pounds
£5.00 GBP:

Euro

To buy in US dollars
$10.00
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THANK YOU!

I should very much like to conduct a clinical trial on the effectiveness of various treatments for FIP, but unfortunately don't have the funding to do so. I'd like to thank Mr Wayne Carr, Maria Bonino and all the other donors to the Angelica FIP trust, to the catvirus subscribers and the EndFIP group, whose generous donations made preliminary investigations possible. Enormous thanks go to the human families of cats who have had FIP, who have generously given of their time, and samples from their cats, to make my research possible and a BIG THANK YOU also to all the veterinary surgeons who have contributed to my studies.

12. References and further reading

Addie D.D., 2004 Feline Infectious Peritonitis. Veterinary Interferon Handbook. Ed: Karine de Mari. Virbac. 108-117

Addie D.D 2008  Feline Infectious Peritonitis   Veterinary Interferon Handbook 2nd edition.  Ed. K. de Mari. Virbac SA, BP 27, O6510 CARROS, France. 132 - 146

Addie D.D.2008  Feline infectious peritonitis – therapy and prevention.  Kirk’s Current Veterinary Therapy XIV Edited by: John D. Bonagura, DVM, MS, DACVIM, David C. Twedt, DVM, DACVIM. Saunders, Elsevier.1295 – 1299

Addie, D.D.. Feline coronavirus. 2012  Infectious Diseases of the Dog and Cat.  4th edition.  Editor: Greene, Craig. Published by W.B. Saunders Elsevier Company, 11830 Westline Industrial Drive, St. Louis, Missouri 63146, USA. ISBN 978-1-4160-6130-4   92-108

Gunn-Moore D, McCann T.  2004 Use of recombinant feline interferon to treat feline infectious peritonitis.  Veterinary Interferon Handbook. Ed. Karine de Mari. Virbac  118-124

Hartmann K, Ritz S.  2008 Treatment of cats with feline infectious peritonitis.  Vet Immunol Immunopathol.  123(1-2):172-5.

Hugo TB, Heading KL. Prolonged survival of a cat diagnosed with feline infectious peritonitis by immunohistochemistry. The Canadian Veterinary Journal. 2015;56(1):53-58.

Ibarrola P, Blackwood L, Graham PA, Evans H, German AJ.  2005 Hypocobalaminaemia is uncommon in cats in the United Kingdom. J Feline Med Surg. 7(6):341-8.

Ishida T, Shibanai A, Tanaka S, Uchida K, Mochizuki M. 2004 Use of recombinant feline interferon and glucocorticoid in the treatment of feline infectious peritonitis. JFMS 6 107-110

Legendre AM, Bartges JW. 2009  Effect of Polyprenyl Immunostimulant on the survival times of three cats with the dry form of feline infectious peritonitis.  J Feline Med Surg. 11 624-626

Legendre AM. 2013 Polyprenyl Immunostimulant presentation to AAHA abstract

Legendre AM, Kuritz T, Galyon G, Baylor VM, Heidel RE. 2017 Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study.  Front Vet Sci. 4:7.

Maunder CL, Day MJ, Hibbert A, Steiner JM, Suchodolski JS, Hall EJ.  2012
Serum cobalamin concentrations in cats with gastrointestinal signs: correlation with histopathological findings and duration of clinical signs. J Feline Med Surg. 14(10):686-93.

Morris JG, Rogers QR.  1978  Arginine: an essential amino acid for the cat.  J Nutr. 108(12):1944-53.

Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies.   Vet Microbiol. 2018 Jun;219:226-233.

O'Brien, DP & Packer, RA (2010) Metabolic encephalopathy: organic acidurias. In August, JR (Ed): Consultations in feline internal medicine. Vol 6. Elsevier Saunders, Philadelphia. pp:595

Pedersen NC, Kim Y, Liu H, Galasiti Kankanamalage AC, Eckstrand C, Groutas WC, Bannasch M, Meadows JM, Chang KO. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. J Feline Med Surg. 2017 Sep 1:1098612X17729626.

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Dr Diane D. Addie 1 August 2018

 

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